The Proteasome: Not Just Degrading Anymore

The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes☆

The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regulators evolved, modifying the function of the 20S core proteasome. Here we summarize shortly the ...

The Proteasome: Not Just Degrading Anymore

with Hsc70 class chaperones; it also may have a lower affinity for the substrates that CSPα unfolds. These studies highlight a dual role for α-synuclein in neurodegeneration: mutant α-synuclein or the abnormal accumulation of wild-type α-synuclein induces neurodegeneration, whereas the normal functions of α-synuclein help to enhance synaptic activity and integrity. A key question is whether and...

Synergistic Anti-Cancer Effects of Second-Generation Proteasome Inhibitor Carfilzomib with Doxorubicin and Dexamethasone Via p53-Mediated Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cells

Background: The ubiquitin-proteasome system (UPS) plays a crucial role in regulating the levels and functions of a large number of proteins in the cell, which are important for cancer cell growth and survival. The proteasome is highly activated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common malignancy in children. The attempt to inhibit proteasome as a ther...

Psychiatric epidemiology: it's not just about counting anymore.

Regulation of Repair by the 26S Proteasome

Cellular processes such as transcription and DNA repair may be regulated through diverse mechanisms, including RNA synthesis, protein synthesis, posttranslational modification and protein degradation. The 26S proteasome, which is responsible for degrading a broad spectrum of proteins, has been shown to interact with several nucleotide excision repair proteins, including xeroderma pigmentosum B ...